Sinteza i biološka ispitivanja derivata prirodnih steroida

Članovi istraživačke grupe:

Kontakt osoba:

Dr Marija Sakač, redovni profesor

marija.sakac@dh.uns.ac.rs

tel: +381-21-485-2772

fax: +381-21-454-065

Rukovođenje aktuelnim projektima:

  • Novel steroid derivatives for anticancer drug development, projekat bilateralne saradnje između Republike Srbije i Republike Austrije; oznaka projekta 337-00-577/2021-09/27; trajanje projekta 2022-2024. Rukovodilac projekta: dr Marina Savić.
  • Novi steroidni derivati – potencijalni hemioterapeutici, projekat Pokrajinskog sekretarijata za nauku i tehnološki razvoj (142-451-3463/2023-01), trajanje projekta: 2021-2024. godine. Rukovodilac projekta: dr Marina Savić
  • Nova metoda skrininga za primenu u usmerenoj evoluciji humanih enzima koji metabolišu steroide, projekat bilateralne saradnje između Republike Srbije i Republike Belorusije; oznaka projekta 337-00-00230/2022-09/09; trajanje projekta: 2022-2024. godine. Rukovodilac projekta: dr Suzana Jovanović-Šanta

Predmet istraživanja

Istraživačka grupa se bavi organskom sintezom i medicinskom hemijom, sa fokusom na steroidna jedinjenja. U biološkim istraživanjima, grupa razmatra višestruke terapeutske potencijale sintetizovanih jedinjenja, uključujući antihormonske, antiinflamatorne, antitumorske i antioksidansne efekte. Pored toga, ispituje se inhibicija enzima koji su ključni u procesu steroidogeneze kao i micelarna svojstva novosintetizovanih steroidnih derivata.

Oprema

  • Bruker Avance III 400 MHz NMR spectrometer
  • Perkin-Elmer SpectrumTwo FTIR spectrometer
  • Microwave Synthesis Sistem-CEM Discover BenchMate

Saradnja

  • Institut tehničkih nauka SANU, Beograd, prof. dr Nenad L. Ignjatović.
  • Tehnološki fakultet, Univerzitet u Novom Sadu, prof. dr Sanja Podunavac-Kuzmanović i prof. dr Lidija Jevrić.
  • Medicinski fakultet, Univerzitet u Novom Sadu, prof. dr Mihalj Poša i prof. dr Ana Pilipović.
  • Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic, dr Pavlína Maloy Rezacova.
  • Institute of Molecular Biology Slovak Academy of Sciences, Bratislava, Slovak Republic, dr Lubica Urbanikova i dr Jacob Bauer.
  • Instituto de Biologia Molecular e Celular, Porto, Portugal, prof dr Vitor Costa.
  • Yale University School of Medicine, New Haven, USA, prof dr Barbara Ehrlich.
  • Faculty of Life Sciences, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria, dr Florian Kopp.
  • Department of Experimental Biology, Faculty of Science, Palacký University, Olomouc, Czech Republic, dr Lucie Rárová.
  • First Department of Medicine, University of Szeged, Szeged, Hungary, dr Mihály Szécsi.
  • Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary, dr István Zupkó.
  • Institute of Bioorganic Chemistry of National Academy of Sciences, Minsk, Belarus, prof. dr Sergey Usanov.
  • Institut za onkologiju, Medicinski fakultet, Univerzitet u Novom Sadu, dr Dimitar Jakimov i dr Vesna Kojić.
  • Institut za biološka istraživanja „Siniša Stanković“, Beograd (Đorđe Miljković)

Ostalo

Članovi tima su uređivali specijalna izdanja međunarodnih časopisa i recenzirali predloge naučnih projekata i veliki broj radova u međunarodnim časopisima. Učestvovali su u realizaciji više nacionalnih i međunarodnih projekata.

 

Reference

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