Sinteza i biološka ispitivanja derivata prirodnih steroida
Članovi istraživačke grupe:
- Dr Marija Sakač, redovni profesor
- Dr Edward Petri, vanredni profesor, Departman za biologiju i ekologiju, Prirodno-matematički fakultet, Univerzitet u Novom Sadu
- Dr Anđelka Ćelić, vanredni profesor, Departman za biologiju i ekologiju, Prirodno-matematički fakultet, Univerzitet u Novom Sadu
- Dr Suzana Jovanović-Šanta, redovni profesor
- Dr Ljubica Grbović, vanredni profesor
- Dr Jovana Ajduković, vanredni profesor
- Dr Andrea Nikolić, vanredni profesor
- Dr Marina Savić, vanredni profesor
- Dr Ksenija Pavlović, vanredni profesor
- Dr Aleksandar Oklješa, vanredni profesor
- Dr Srđan Bjedov, docent
- Dr Ivana Kuzminac, naučni saradnik
- Dr Sofija Bekić, naučni saradnik
- Dr Maja Marinović, naučni saradnik, Departman za biologiju i ekologiju, Prirodno-matematički fakultet, Univerzitet u Novom Sadu
- MSc Milica Stevanović, istraživač-pripravnik
- MSc Đorđe Janković, istraživač-pripravnik
- MSc Ljubica Brenjo, istraživač-pripravnik
Kontakt osoba:
Dr Marija Sakač, redovni profesor
tel: +381-21-485-2772
fax: +381-21-454-065
Rukovođenje aktuelnim projektima:
- Novel steroid derivatives for anticancer drug development, projekat bilateralne saradnje između Republike Srbije i Republike Austrije; oznaka projekta 337-00-577/2021-09/27; trajanje projekta 2022-2024. Rukovodilac projekta: dr Marina Savić.
- Novi steroidni derivati – potencijalni hemioterapeutici, projekat Pokrajinskog sekretarijata za nauku i tehnološki razvoj (142-451-3463/2023-01), trajanje projekta: 2021-2024. godine. Rukovodilac projekta: dr Marina Savić
- Nova metoda skrininga za primenu u usmerenoj evoluciji humanih enzima koji metabolišu steroide, projekat bilateralne saradnje između Republike Srbije i Republike Belorusije; oznaka projekta 337-00-00230/2022-09/09; trajanje projekta: 2022-2024. godine. Rukovodilac projekta: dr Suzana Jovanović-Šanta
Predmet istraživanja
Istraživačka grupa se bavi organskom sintezom i medicinskom hemijom, sa fokusom na steroidna jedinjenja. U biološkim istraživanjima, grupa razmatra višestruke terapeutske potencijale sintetizovanih jedinjenja, uključujući antihormonske, antiinflamatorne, antitumorske i antioksidansne efekte. Pored toga, ispituje se inhibicija enzima koji su ključni u procesu steroidogeneze kao i micelarna svojstva novosintetizovanih steroidnih derivata.
Oprema
- Bruker Avance III 400 MHz NMR spectrometer
- Perkin-Elmer SpectrumTwo FTIR spectrometer
- Microwave Synthesis Sistem-CEM Discover BenchMate
Saradnja
- Institut tehničkih nauka SANU, Beograd, prof. dr Nenad L. Ignjatović.
- Tehnološki fakultet, Univerzitet u Novom Sadu, prof. dr Sanja Podunavac-Kuzmanović i prof. dr Lidija Jevrić.
- Medicinski fakultet, Univerzitet u Novom Sadu, prof. dr Mihalj Poša i prof. dr Ana Pilipović.
- Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic, dr Pavlína Maloy Rezacova.
- Institute of Molecular Biology Slovak Academy of Sciences, Bratislava, Slovak Republic, dr Lubica Urbanikova i dr Jacob Bauer.
- Instituto de Biologia Molecular e Celular, Porto, Portugal, prof dr Vitor Costa.
- Yale University School of Medicine, New Haven, USA, prof dr Barbara Ehrlich.
- Faculty of Life Sciences, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria, dr Florian Kopp.
- Department of Experimental Biology, Faculty of Science, Palacký University, Olomouc, Czech Republic, dr Lucie Rárová.
- First Department of Medicine, University of Szeged, Szeged, Hungary, dr Mihály Szécsi.
- Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary, dr István Zupkó.
- Institute of Bioorganic Chemistry of National Academy of Sciences, Minsk, Belarus, prof. dr Sergey Usanov.
- Institut za onkologiju, Medicinski fakultet, Univerzitet u Novom Sadu, dr Dimitar Jakimov i dr Vesna Kojić.
- Institut za biološka istraživanja „Siniša Stanković“, Beograd (Đorđe Miljković)
Ostalo
Članovi tima su uređivali specijalna izdanja međunarodnih časopisa i recenzirali predloge naučnih projekata i veliki broj radova u međunarodnim časopisima. Učestvovali su u realizaciji više nacionalnih i međunarodnih projekata.
Reference
- Ajduković, J., Penov Gaši, K., Jakimov, D., Klisuric, O., Jovanovic-Šanta, S., Sakač, M., Aleksić, L., Djurendic, E. (2015): Synthesis, structural analysis and antitumor activity of novel 17α-picolyland 17(E)-picolinylidene A-modified androstane derivatives. Bioorganic & Medicinal Chemistry 23: 1557-1568. https://doi.org/10.1016/j.bmc.2015.02.001
- Savić, , Djurendić, E., Petri, E., Ćelić, A., Klisurić, O., Sakač, M., Jakimov, D., Kojić, V., Penov Gaši, K. (2013) Synthesis, structural analysis and antiproliferative activity of some novel D-homo lactone androstane derivatives, RSC Advances 3:10385-10395 https://doi.org/10.1039/C3RA41336E
- Stevanović, M. Z., Bekić, S. S., Petri, T., Ćelić, A. S., Jakimov, D. S., Sakač, M. N., Kuzminac, I. Z. (2024): Synthesis, in vitro And in silico Anticancer Evaluation of Novel Pyridin-2-yl Estra-1,3,5(10)-triene Derivatives, Future Medicinal Chemistry https://doi.org/10.4155/fmc-2024-0039
- Nikolić, A. R., Kuzminac, I. Z., Petri, E. T., Ćelić, A. S., Sakač, M. N. (2024): A Search for Sars-CoV-2 Main Protease Inhibitors: Synthesis and Docking Study of Steroidal Dinitriles. ChemistrySelect 9: e202304164. https://doi.org/10.1002/slct.202304164
- Šestić, Lj., Ajduković, J., Bekić, S., Ćelić, A., Stojanović, S., Najman, S., Marinović, M., Petri, E., Škorić, D., Savić, M. (2023): Novel D-modified heterocyclic androstane derivatives as potential anticancer agents: Synthesis, characterization, in vitro and in silico Journal of Steroid Biochemistry and Molecular Biology 223: 106362. https://doi.org/10.1016/j.jsbmb.2023.106362
- Šestić, Lj., Ajduković, Marinović, M., Petri, E., Savić, M. (2023): In silico ADMET analysis of the A-, B- and D-modified androstane derivatives with potential anticancer effects. Steroids 189: 109147. https://doi.org/10.1016/j.steroids.2022.109147
- Kovačević, S., Karadžić Banjac, M., Podunavac-Kuzmanović, S., Ajduković, J., Salaković, B., Rárová, L., Đorđević, M., Ivanov, M. (2023): Local QSAR modeling of cytotoxic activity of newly designed androstane 3-oximes towards malignant melanoma cells. Journal of Molecular Structure 1283: 135272. https://doi.org/10.1016/j.molstruc.2023.135272
- Kuzminac, I., Savić, M., Ajduković, J., Nikolić, A. (2023): Steroid and Triterpenoid Compounds with Antiparasitic Properties (Review Article). Current Topics in Medicinal Chemistry 23: 791-815. https://dx.doi.org/10.2174/1568026623666230126162419
- Ilić, M., Pastor, K., Marković, J., Grbović, Lj., Jovanović-Šanta, S., Mitrović, I., Trivunović, Z., Ačanski, M. (2022): Feasibility study of separation and purification of bile acid derivatives by HPLC on C18 and F5 columns. Steroids. 186. https://doi.org/10.1016/j.steroids.2022.109074
- Marinović, M., Petri, E., Grbović, Lj., Vasiljević, B., Jovanović-Šanta, S., Bekić, S., Ćelić, A. (2022): Investigation of the potential of bile acid methyl esters as inhibitors of aldo-keto reductase 1C2: insight from molecular docking, virtual screening, experimental assays and molecular dynamics Molecular Informatics. 41. https://doi.org/10.1002/minf.202100256
- Kuzminac, I., Ćelić, A., Bekić, S., Kojić, V., Savić, M., Ignjatović, N. (2022): Hormone receptor binding, selectivity and cytotoxicity of steroid D-homo lactone loaded chitosan nanoparticles for the treatment of breast and prostate cancer cells, Colloids and Surfaces B: Biointerfaces216:112597 https://doi.org/10.1016/j.colsurfb.2022.112597
- Savić, M., Sakač, M., Kuzminac, I., Ajduković, J. (2022): Structural diversity of bioactive steroid compounds isolated from soft corals in the period 2015–2020 (Review). Journal of Steroid Biochemistry and Molecular Biology 218: 106061. https://doi.org/10.1016/j.jsbmb.2022.106061
- Kuzminac, I., Bekić, S., Ćelić, A., Jakimov, D., Sakač, M. (2022): Antitumor potential of novel 5α,6β-dibromo steroidal D-homo lactone, Steroids188:109118 https://doi.org/10.1016/j.steroids.2022.109118
- Kuzminac, I., Jakimov, D., Bekić, S., Ćelić, A., Marinović, M., Savić, M., Raičević, V., Kojić, V., Sakač, M. (2021): Synthesis and anticancer potential of novel 5,6-oxygenated and/or halogenated steroidal D-homo lactones, Bioorganic & Medicinal Chemistry30:115935 https://doi.org/10.1016/j.bmc.2020.115935
- Ajduković, J., Jakimov, D., Rárová,, Strnad, M., Dzichenka, Y., Usanov, S., Škorić, D., Jovanović-Šanta, S., Sakač, M. (2021): Novel alkylaminoethyl derivatives of androstane 3-oximes as anticancer candidates: Synthesis and evaluation of cytotoxic effect. RSC Advances 11: 37449-37461. https://doi.org/10.1039/D1RA07613B
- Kulmány, Á., Herman, B., Zupkó, I., Sinreih, M., Rižner, T., Savić, , Oklješa, A., Nikolić, A., Nagy, V., Ocsovszki, I., Szécsi, M., Jovanović-Šanta, S. (2021) Heterocyclic androstane and estrane D-ring modified steroids: microwave-assisted synthesis, steroid-converting enzyme inhibition, apoptosis induction, and effects on genes encoding estrogen inactivating enzymes, Journal of Steroid Biochemistry and Molecular Biology 214:105997. https://doi.org/10.1016/j.jsbmb.2021.105997
- Dzichenka, Y., Shapira, M., Yantsevich, A., Cherkesova, T., Grbović, Lj., Savić, , Usanov, S., Jovanović-Šanta, S. (2021) Modified bile acids and androstanes – Novel promising inhibitors of human cytochrome P450 17A1, Journal of Steroid Biochemistry and Molecular Biology 205:105777. https://doi.org/10.1016/j.jsbmb.2020.105777
- Savić, , Kuzminac, I., Škorić, D., Jakimov, D., Rárová, L., Sakač, M. N., Djurendić, E. (2020) New oxygen-containing androstane derivatives: Synthesis and biological potential, Journal of Chemical Sciences 132:98 https://doi.org/10.1007/s12039-020-01803-3
- Savić, , Škorić, D., Kuzminac, I., Jakimov, D., Kojić, V., Rárová, L., Strnad, M., Djurendić, E. (2020) New A-homo lactam D-homo lactone androstane derivative: Synthesis and evaluation of cytotoxic and anti-inflammatory activities in vitro, Steroids 157:108596 https://doi.org/10.1016/j.steroids.2020.108596
- Dzichenka, Y., Shapira, M., Yantsevich, A., Cherkesova, T., Grbović, Lj., Savić, M., Usanov, S., Jovanović-Šanta, S. (2020): Modified bile acids and androstanes – Novel promising inhibitors of human cytochrome P450 17A1. Journal of Steroid Biochemistry and Molecular Biology. 205. https://doi.org/10.1016/j.jsbmb.2020.105777
- Vasiljević, B., Petri, E., Bekić, S., S. Ćelić, A., Grbović, Lj., Pavlović, K. (2020):
Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding. RSC Medicinal Chemistry. 12: 278. https://doi.org/10.1039/D0MD00311E - Vraneš, M., Papović, S., Idrissi, A., Zec, N., Panaget, T., Ajduković, J., Gadžurić, S. (2019): New methylpyridinium ionic liquids – Influence of the position of –CH3 group on physicochemical and structural properties. Journal of Molecular Liquids 283: 208-220. https://doi.org/10.1016/j.molliq.2019.03.075
- Savić, M., Ajduković, J., Plavša, J., Bekić, S., Ćelić, A., Klisurić, O., Jakimov, D., Petri, E., Djurendić, E. (2018): Evaluation of A-ring fused pyridine D-modified androstane derivatives for antiproliferative and aldo–keto reductase 1C3 inhibitory activity. Medicinal Chemistry Communications 9: 969- https://doi.org/10.1039/C8MD00077H
- Grbović, Lj., Vasiljević, B., Pavlović, K., Hajnal-Jafari, T., Đurić, S., Popsavin, M., Kevrešan, S. (2018): Microwave-assisted synthesis of biologically active amide derivatives of naphthenic acids under neat conditions. Macedonian Journal of Chemistry and Chemical Engineering. 37: 13. https://doi.org/10.20450/mjcce.2018.1371