Group memebers:
- Dr Janoš Čanadi, Full Professor
- Dr Marija Sakač, Full Professor
- Dr Mihalj Poša, Full Professor, Faculty of Medicine, University of Novi Sad
- Dr Ljubica Grbović, Associate Professor
- Dr Ana Pilipović, Associate Professor, Faculty of Medicine, University of Novi Sad
- Dr Ksenija Pavlović, Associate Professor
- Dr Srđan Bjedov, Assistant Professor
- Dr Vesna Tepavčević, Assistant Professor, Faculty of Medicine, University of Novi Sad
- Dr Dejan Ćirin, Teaching Assistant, Faculty of Medicine, University of Novi Sad
- Dr Bojana Vasiljević, Research Associate
- MSc Dušan Škorić, Research Assistant
Contact person:
Dr Janoš Čanadi, Professor
janos.canadi@dh.uns.ac.rs
tel: + 381 21 485 2773
fax: +381-21-454-065
On-going projects:
Synthesis, characterization and biological studies of steroid derivatives and their molecular aggregates
the Ministry of Education, Science and Technological Development of the Republic of Serbia
Project number: 172021
Duration: 2011-2019
Project leader: Prof. dr Marija Sakač
Research focus
Two former professors Dr Dušan Miljković and Dr Jovan Hranisavljević have created this scientific research group at the seventies of the last century at the Institute of Chemistry. Originally, the scientific research was focused on the isolation of cholic and hyocholic acid from naturally affordable row materials (beef and pork bile), as well as the transformation of the most prevalent bile acids into other derivatives with promising pharmaceutical use (for example, the synthesis of chenodeoxycholic acid from cholic acid). In those years, intensive and fruitful cooperation was established with researchers from Galenika Pharmaceuticals in Belgrade and Faculty of Medicine in Novi Sad. More recently, the research leaders are professors Dr Marija Sakač, Dr Janoš Čanadi and Dr Mihalj Poša. The topic of today’s research is related to synthesis of bile acid derivatives and testing of their micellar properties. For these physical and chemical tests, the modern instrumental methods are used (NMR spectroscopy, FTIR, fluorescence spectrometry, microcalorimetry, Langmuir scale). Good cooperation has been established with the professors of the University of Szeged and Debrecen through one IPA project.
Equipment
- Bruker Avance III 400 MHz NMR spectrometer
- Perkin-Elmer SpectrumTwo FTIR spectrometer
- Microwave Synthesis Sistem-CEM Discover BenchMate
- High-pressure laboratory autoclave Roth Karlsruhe (100 mL)
- Agilent Cary Eclipse Fluorescence Spectrophotometer (Faculty of Medicine, University of Novi Sad)
- Radiometer Analytical Tim 870 Titration Menager (Faculty of Medicine, University of Novi Sad)
- HPLC, Agilent 1100 series, with binary pump, autosampler and a diode array UV/Vis detector (Faculty of Medicine, University of Novi Sad)
- Krüss tensiometer (du Noüy ring method) (Faculty of Medicine, University of Novi Sad)
Collaborations
- Department of Chemistry, Faculty of Science and Technology, University of Debrecen and University of Szeged (prof. dr Gyula Batta and prof. dr Etelka Tombácz)
- The Institute for Solid State Physics, Hungarian Academy of Sciences
- Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad (dr Dimitar Jakinov and dr Vesna Kojić)
References
- Ilić, M., Pastor, K., Marković, J., Grbović, Lj., Jovanović-Šanta, S., Mitrović, I., Trivunović, Z., Ačanski, M. (2022): Feasibility study of separation and purification of bile acid derivatives by HPLC on C18 and F5 columns. Steroids. 186. doi: 10.1016/j.steroids.2022.109074
- Marinović, M., Petri, E., Grbović, Lj., Vasiljević, B., Jovanović-Šanta, S., Bekić, S., Ćelić, A. (2022): Investigation of the potential of bile acid methyl esters as inhibitors of aldo-keto reductase 1C2: insight from molecular docking, virtual screening, experimental assays and molecular dynamics Molecular Informatics. 41. doi: 10.1002/minf.202100256
- Dzichenka, Y., Shapira, M., Yantsevich, A., Cherkesova, T., Grbović, Lj., Savić, M., Usanov, S., Jovanović-Šanta, S. (2020): Modified bile acids and androstanes – Novel promising inhibitors of human cytochrome P450 17A1. Journal of Steroid Biochemistry and Molecular Biology. 205. doi: 10.1016/j.jsbmb.2020.105777
- Vasiljević, B., Petri, E., Bekić, S., S. Ćelić, A., Grbović, Lj., Pavlović, K. (2020):
Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding. RSC Medicinal Chemistry. 12: 278. doi: 10.1039/D0MD00311E - Grbović, Lj., Vasiljević, B., Pavlović, K., Hajnal-Jafari, T., Đurić, S., Popsavin, M., Kevrešan, S. (2018): Microwave-assisted synthesis of biologically active amide derivatives of naphthenic acids under neat conditions. Macedonian Journal of Chemistry and Chemical Engineering. 37: 13. doi: 10.20450/mjcce.2018.1371