Istraživačka grupa za sintezu prirodnih proizvoda i medicinsku hemiju

Group memebers:

Contact person:

Professor Velimir Popsavin

velimir.popsavin@dh.uns.ac.rs

tel: +381 21 485 27 68

fax: +381 21 454 065

On-going projects:

Synthesis and biological testing of new mimics or derivatives of selected cytotoxic lactones, antitumor agent tiazofurin and natural naphthenic acids.

Fundamental project of the Ministry of Education, Science and Technological Development of Republic of Serbia.

Project number: OI 172006

Duration: 2011–2019.

Project leader: Professor Velimir Popsavin

Research focus

Basic research directed to the development of novel routes for the total synthesis of natural cytotoxic lactones and their analogs, as well as for the de novo synthesis of potential bioisosteres of antineoplastic C-nucleoside tiazofurin. In addition, the evaluation of in vitro anti-tumour activity of synthesized compounds toward the selected human neoplastic cell lines is currently under way.

Equipment

Bruker 400 MHz NMR spectrometer; BUCHI Laboratory Vacuum System; BUCHI 510 Melting Point aparatus; JULABO FT902 Immersion Cooler.

 

Collaborations

School of Chemistry, University of Leeds, UK; Institute of Biochemistry, Kossuth Lajos University, Debrecen, Hungary; Central Research Institute for Chemistry Hungarian Academy of Sciences, Budapest, Hungary; Laboratory for Chemical and Mineralogical Crystallography, Bern University, Switzerland; Oncology Institute of Vojvodina, Sremska Kamenica, Serbia; Department of Chemistry ICTM, Belgrade, Serbia; Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia; Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.

Other

Team members reviewed a large number of scientific papers for international journals, as well as numerous local and international projects.